Protein Shapes Matter in Alzheimer’s Research

From time to time proteins misfold. When that comes about in the human brain, the pileup of misfolded
proteins can direct to neurodegenerative diseases like Alzheimer’s, Parkinson’s and

Proteins do not misbehave and misfold out of the blue. There is a sensitive ecosystem
of biochemical interactions and environments that normally allow them twist, unfold,
refold and do their jobs as they are meant to. 

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However, as researchers from Michigan Technological University check out in an posting
published in
ACS Chemical Neuroscience, even a compact adjust might bring about extensive-phrase outcomes. 

For amyloid beta peptides — considered a main hallmark of Alzheimer’s sickness — a 
widespread chemical modification at a specific area on the molecule has a butterfly
outcome that sales opportunities to protein misfolding, aggregation and mobile toxicity. 

Acetylation and Amyloid Beta Toxicity

Ashutosh Tiwari, associate professor of chemistry at Michigan Tech, describes that misfolded

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